The antibiotic broad spectrum of automotive penicillin, ampicillin, carbenitsillin, ampiox. They have bactericidal activity as gramotricationuyu or grampolaugitionuyu flora; A wide range of activity also have zefalosporin and aminoglikozida, automotive tetratziklin. Combined use of antibiotics especially shown in microbial associations. In selecting antibiotics should be taken into account distribution in the body, perhaps the interactions between them, which could be sinergidnym, antagonistic or indifferent. The best option is a combination of drugs with sinergidnym action. At the same time the use of drugs with different mechanism of action and sensitivity function should be to all antibiotics within combination. Synergy among antibiotics is the best medicine in a group of microbicides or bakteriostaticski action. The best combination of antibiotics with different range, but the combination of antibiotics belonging to a class of drugs (aminoglikozida, tetratziklin, makrolida etc.), it is not recommended that it would be dangerous to the summation of adverse events (toxic effect). For example, and nefrotoksicescoe ototoksicescoe the aminoglikozidov (streptomycin, kanamycin, monomicin, gentamicin, etc.) increases with the cost of these drugs, or replacing one another drug from the same group. Exceptions include antibiotics пенициллинов groups, including automotive. The need, in some cases, dual use penitsillinov determined to different spectrum. Combined use of antibiotics only effective when one of the products made at the microbial cell and the other is the sinergidnyi (multiplier) effect, or the drugs together. When gnano-vospalitiona surgical diseases caused by mixed infection, high efficiency with a combination of derivatives and penitsillinov aminoglikozidov. The infections caused by proteem, the answer may be a combination of carbenitsillina and aminoglikozidov. When gnano-vospalitiona Diseases caused by the anaerobic flora nesporoobrazoutei or mixed aerobic and anaerobic infection has been shown treated with antibiotics macrolidna Group (erythromycin), linkomitinom, levomicetinom. The most effective in combination with aminoglikozidami. High efficiency for nesporoobrazuth anaerobov with metronidazole (trihopol). The best combinations of antibiotics in respect of any infectious abdominal infection were : Staphylococcus golden-metitillin and kanamycin; Protei - ampicillin and kanamycin; Ampicillin and gentamicin; Penicillin and gentamycin; Sinegnanaya wand-carbenitsillin and gentamycin; Carbenitsillin and kanamycin; Klebsiella - zefalosporin and kanamycin; enterokock - zefalosporin and streptomycin, penicillin and streptomycin; penicillin and kanamycin; ampicillin and streptomycin. The use of antibiotics in abdominal surgery are varied. Widely detected intramuscular route. In the early years of local antibiotics use penicillin in the treatment of purulent wounds proved to be more effective than the injection.