The same drugs used and ulcers duodenal ulcer. To protect the mucous membrane of stomach and duodenal ulcer long been used drugs bismuth (bismuth nitrate in the 0.3-0.5 g 2-3 times per day). Currently, a great success using коллоидный субцитрат bismuth (де-нол), which combine with the squirrels, NACRO in язвенном эрозивном and defects formed around them insoluble преципитат covering the mucous membranes белково-висмутовой film. De-nol appoint two pills within 30 minutes before eating 3-4 times a day. Another product formed on the surface of mucous membranes protective layer rezistennetary the destructive effects of hydrochloric acid and pepsina - sukralfat. Assign medication one tablet three times a day for 30 to 40 minutes before eating, and the 4th time at night. De-nol and sukralfat especially shows patients who are unable to stop smoking because smoking is several times less effective blocking N2-retseptorov. Product, which contains both bismuth and blokator N2-retseptorov is ranitidine (pilorid, gistak, ranisan). It has protective properties against mucous membrane and the ability to suppress H.pylori. Destruction of H.pylori, bacteria, infectious mucous membrane of the stomach and duodenal ulcers, now is a prerequisite for the treatment of ulcers. This integrated therapy, which includes a de-nola, trihopola antibiotic and have contributed to the elimination of the active inflammatory process in gastroduodenal mucosal lining, the existence of which depends to a great extent the length of remission ulcers. Enlisting the regeneration mucous membrane is the appointment of the so-called reparantov facilities affecting the fabric exchange. These include oksiferriskorbon sodium (daily 50 mg intramuscularly), solcoseril (2-4 ml per injection), metronidazole, or trihopol (on the inside of 0.25 g 3-4 times per day), vitamins B1, B2, B6, extract maximum (in Russia). In clinical practice, in recent years, introduced new products, synthetic analogues prostaglandines. Synthetic analogue of prostaglandin E1-rioprostil - has expressed antisecretorian effect vsokoeffectiven also enprostil (analogue of prostaglandin E2). Synthetic analogue enkefalinov - dalargin are similar zimetidinu time rubtsevania ulceration and a longer remission of the disease. Physical methods of treatment is the heat during stihania deterioration (application paraffin, ozocerite) in the period neoslojnennom disease and the absence of a concealed haemorrhage. The term does not rubtsuthan ulcers, especially in patients aged and elderly age are using the integrated Outlook therapy so as to reduce the hypoxia mucous membrane exposed body. Finally, there is a positive experience with radiation lesions defect laser (through fibrogastroshop), 7-10 sessions exposures substantially shorten the time rubtsevania. In some cases, there is a need for surgery. Surgery patients showed ulcers with frequent recurrence of the continuous therapy supporting protivoyazvennah doses of drugs. The operation is shown in the cases of penetration, ulcer perforation, stenosis piloroduodenalnogo division expressed evaquatoriani violations and profuzne gastrointestinal hemorrhage.