Furthermore, the use of "systemic" fungicidal products often accompanied by side effects, in particular, the development of toxic hepatitis. By virtually neadsorbirutmsa antimikoticski will include levorin, nystatin and natamizin (Pimafuzin). Appointment levorina nistatina and with a sufficiently high frequency accompanied by the development of side effects (despepsiceskie phenomenon, allergies, chronic hepatitis). Pimafuzin (natamizin) - protivogribkovi polienovy antibiotic broad spectrum. And antifungal potential. Pimafuzin links sterola cell membranes, disrupting their integrity and function, leading to the death of microorganisms. By natamitino most sensitive pathogenic yeast fungi, the most - Candida albicans. Pimafuzin has a higher efficiency than nistatinom. No resistance natamitino in clinical practice not seen; In multiples of the minimum preparation overwhelming concentration in the C.albicans does not change. Pimafuzin tablets are only proswete bowel little absorbed from the gastrointestinal tract. In applying tablets in the first days of treatment may despepsiceskie phenomenon, nausea and diarrhoea, which do not require the preparation and to be settled during the course of treatment. The only opportunity of [pimafucyna is increased sensitivity to components of the preparation. Pimafuzin may be nominated during pregnancy and lactation, as well as newborn children. To treat gastrointestinal candidiasis needed treatment nevsasavatmisa fungicide products within 7-10 days. Nystatin appoint 250,000 U 6-8 times a day (daily intake to 3 million U) within 14 days. His appoint 100 mg (1 tablet) 2-4 times a day for 7-10 days. We must acknowledge that the tactics treatment candidiasis mucous membranes vnekishecna localization only local fungicide means or drugs systemic action vsasavatmisa from the gastrointestinal tract, inherently flawed. Since limfogematogennogo source of virulent strains of Candida causing systemic candidiasis is the intestine, without suppressing the growth of mushrooms in his proswete fungicidal therapy is ineffective or only a short-term effect unstable. The systems 4-8 nistatina dose can be increased to 4 million U / day, while a current Local antimycotic resort. The systems 4-8 pimafuzin used in the same dose, while the appointment of Local Fungus funds. In severe cases, the treatment of additional drugs for systemic effects. Of particular importance are early detection and therapy of gastrointestinal candidiasis prevention systematic and generalized candidiasis in patients at risk, which include, above all patients receiving protivoopujolevu radiation and / or chemotherapy, TB drugs, patients pre-planned operations on the abdomen. In these situations, most preferably a nevsasavathan fungicidal products, as their long and reintegration does not significantly affect the farmakodinamiku other drugs. The main criterion for the effectiveness of therapy is not a negative result for planting mushrooms, but, first and foremost, the disappearance of the symptoms, the normalization of mushrooms on the Mycological studies (with the possibility of an intestinal planting contents). To achieve economies of often had to resort to re-treatment rates.