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PostSubject: high efficiency   Fri Apr 06, 2007 9:31 pm

The air handling with an estimated at 40 kg 10% dusta per hectare, with a helicopter-20 kg / ha. The ground handling spend 30 dusta kg per hectare. Length effect one protivoklestseva processing is typically 5-8 years. The locations of facilities are mandatory cleaning up from the weeds, wood, debris, small shrubs. In some cases, effective measure is spring burning grass weeds. Of course, this method can be applied in limited areas, with the usual precautions in advance of the growing season. In late territories affected by kleshchevomu riccetsiosu, it is necessary to include activities conducive to radically destroy mites : clear land territory clearing in the forest included in the residential zone, a tree-type park, the construction of improved roads. The transplantation of bone marrow (TCM) is a method of treating acute blood, cancer and some tumorous disease, in which patients after stomach (destruction) kostnomozgovy blood as a result of excessive doses of drugs and (or) radiation therapy introduced blood or own bone marrow taken before chemotherapy and (or) radiation therapy. The TCM significantly extends and enhances the treatment of many serious diseases. Currently, in the world every year, more than 10,000 operations and bezretidius five-year survival of patients after TCM reaches 50-80%. Early reports on the treatment of bone marrow are 90th respectively. The 19th century. While at the same time in several countries has been used extract bone marrow for the treatment of blood disorders. Over the next 50 years, there have been several attempts to treat diseases of the blood through oral, intraosteal, intramuscular and intravenous bone marrow, but they do not go beyond the scope of clinical experiments. Intensive development of the scientific basis for bone-marrow transplants (TCM) began immediately after the end of the Second World War, which is connected with the use of nuclear weapons in Hiroshima and Nagasaki. In 1950 it was found that intravenous suspension spleen cells after lethal doses leads to the restoration of normal blood and survival of animals. In the mid-1950s respectively. have been successfully implemented Autologous T, but the first allogenne TCM yielded disappointing results : long prizivlenie allogennogo bone marrow was less than 1% of patients. Only by the end of the 1960s. , The development of adequate harvesting and storage of bone marrow, the opening of HLA / decrypt its importance in the prizivlenia allotransplantata, deal with the prevention and treatment of reaction "against transplant owner (RTPH), it has become possible to use TCM in clinical practice. There are two main types of T : allogennouu (Altkm), in which the patient is introduced bone marrow donor; Autologicnuu (ATKM), when the patient receives his bone marrow taken before himio and (or) radiation therapy. Variety is Altkm singennaya transplantation - km from odnoyaytsevy twins. Since the mid-1980s. using another method, transplanting blood stem cells (CCTS), harvested using cell separators. More than three clinical experience in the application of TCM will develop detailed testimony to the type of transplantation : Key testimony in TCM indications allogeneic T indications autologicna TCM nelimpoblastny acute leukaemia (first dose), acute lymphoblastic leukaemia (second remission or first remission with the risk), chronic mielolakoz deployed in the Mielodisplasticeski syndrome Severe aplastic anaemia Heavy congenital combined immunodeficita Heavy haemoglobinopathies Diseases accumulation Limfogranulematos (second remission and and the first remission with the risk factors) fell Malignant lymphomas highly zlokacestvennosti (second or first remission with the risk factors) Mielomnaya illness Some solid tumours (neiroblastoma, Uinga sarcoma, breast cancer, testes, ovaries, melcockletocny lung cancer) Despite high efficiency Altkm had a number of shortcomings. First, gistosovmestimae donors have no more than 10 to 15% of patients. Secondly, even with the compatibility of Hla-sisteme in 40-60% of patients RTPH develops, which leads to death 30 to 50% of them. Moreover, against the backdrop of RTPH sharply increases the risk of serious infectious complications, especially zhitomegalovirusnoho pnevmonita, with 60-80% charge rate. Operation transplantation monoclonal antibody can, in most cases, prevent RTPH. but dramatically increases the frequency of relapses because of the lack of response "to the transplant leukemia." The ATKM has a number of advantages over Altkm : * no need to search gistosovmestimogo donor. * RTPH absence; * faster restoration of immunological status Therefore, in gemoblastozah without defeat bone marrow, especially limfogranulematose (LGM), and malignant NHL limfomah (ZNL), the method of choice is ATKM.

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