The third of the patients spontaneously stabilize or cut. For acute disseminirovannogo histoplasmosis typical fever, hepatosplenomegaly, limfadenopatia, jaundice, and pancitopenia ray picture reminiscent miliarnyi tuberculosis. The 25% of patients indicate indurirovanne izgyazwlenia in mouth, the mucous lining language, nose or throat. In patients with HIV infection can develop disseminated the years after the stay in a geographically hazardous area. Pathological results of the X-ray study (uzlovatae and miliarnae shadows), in 50% of patients. Histoplasmosis syndrome eye is specific uweitom (with a positive skin test to gistoplazmin) amidst signs of a strong histoplasmosis in the body. Diagnosis requires kulturalnogo histology or confirmation. The serological studies serum or liquor can be lozhnopolaugitionami or lozhnootricationami; RCC in the epidemiologist, above or equal to 1 : 32 questionable; There can also be cross-serotype antigens with the Brazilian. Skin testing in acute infection is irrelevant and may cause serokonvershiyu. Treatment with acute gistoplazmoze light treatment is not required. Patients with chronic pulmonary and disseminirovannam dynamics shows the amfoteritina The dose of 0.4-0.5 mg / kg / day or in a double dose of the day for a period of 10 weeks. Ketokonazol or intrakonazol - Alternative drugs in patients with a moderate problem. Ketokonazol a dose of 400 mg / day, but the dose may be increased to 800 mg / day, if the response to treatment is not optimal. Intrakonazola dose 200 mg / day or twice a day. Patients with HIV and disseminirovannam dynamics more shows amphotericin B than ketokonazol. After the main part of the treatment shall amphotericin B dose of 1 mg / kg weekly intrakonazol or 200 mg / day in a preventive mode. The acute and chronic blastomikoz light Infection occurs by inhalation man mushrooms from the soil, decomposing plants or decaying wood. This is an unusual disease, the majority of cases are found in the south-eastern, central and Middle states of the USA.